SNFGE SNFGE
 
Thématique :
- Foie
Originalité :
Très original
Solidité :
Très solide
Doit faire évoluer notre pratique :
Dans certains cas
 
 
Nom du veilleur :
Professeur Christine SILVAIN
Coup de coeur :
 
 
Hepatology
  2016/03  
 
  2016 Mar;63(3):712-20  
  doi: 10.1002/hep.28384  
 
  Acute and Chronic Hepatitis E Virus Infection in Human Immunodeficiency Virus-Infected U.S. Women.  
 
  Kuniholm MH, Ong E, Hogema BM, Koppelman M, Anastos K, Peters MG, Seaberg EC, Chen Y, Nelson KE, Linnen JM  
  http://www.ncbi.nlm.nih.gov/pubmed/26646162  
 
 

Exposure to hepatitis E virus (HEV) is common in the United States, but there are few data on prevalence of HEV/human immunodeficiency virus (HIV) coinfection in U.S.

POPULATIONS:

We tested 2,919 plasma samples collected from HIV-infected (HIV(+) ) women and men enrolled in U.S. cohort studies for HEV viremia using a high-throughput nucleic acid testing (NAT) platform. NAT(+) samples were confirmed by real-time polymerase chain reaction. Samples were selected for testing primarily on the basis of biomarkers of liver disease and immune suppression. Prevalence of HEV viremia was 3 of 2,606 and 0 of 313 in tested plasma samples collected from HIV(+) women and men, respectively. All HEV isolates were genotype 3a. Based on follow-up testing of stored samples, 1 woman had chronic HEV infection for >4 years whereas 2 women had acute HEV detectable at only a single study visit.

CONCLUSIONS:

To our knowledge, this is the first reported case of chronic HEV infection in an HIV(+) U.S. individual. We also confirm that chronic HEV infection can persist despite a CD4(+) count >200 cells/mm(3) . Overall, though, these data suggest that HEV infection is rare in the HIV(+) U.S.

POPULATION:

(Hepatology 2016;63:712-720).

 
Question posée
 
Etude aux USA de la prévalence du VHE par NAT et confirmation par PCR chez les patients VIH ayant un bilan sanguin avec anomalie du bilan hépatique ou un bilan pour évaluation de l’immunosuppression.
 
Question posée
 
3 cas confirmés chez les 2606 femmes et 0 cas sur les 313 hommes testés avec 3 génotypes 3a et une infection chronique.
 
Commentaires

L’hépatite E est rare aux USA chez les patients VIH avec un risque de passage à la chronicité mise en évidence alors que CD4 >200 /mm3.

 
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