SNFGE SNFGE
 
Thématique :
- Foie
Originalité :
Réexamen
Solidité :
Très solide
Doit faire évoluer notre pratique :
Dans certains cas
 
 
Nom du veilleur :
Professeur Christine SILVAIN
Coup de coeur :
 
 
Hepatology
  2017/02  
 
  2017 Feb;65(2):426-438.  
  doi: 10.1002/hep.28901  
 
  The association between race/ethnicity and the effectiveness of direct antiviral agents for hepatitis C virus infection.  
 
  Su F, Green PK, Berry K, Ioannou GN  
  https://www.ncbi.nlm.nih.gov/pubmed/27775854  
 
 

Abstract

Black race and Hispanic ethnicity were associated with lower rates of sustained virologic response (SVR) to interferon-based treatments for chronic hepatitis C virus infection, whereas Asian race was associated with higher SVR rates compared to white patients. We aimed to describe the association between race/ethnicity and effectiveness of new direct-acting antiviral regimens in the Veterans Affairs health care system nationally. We identified 21,095 hepatitis C virus-infected patients (11,029 [52%] white, 6,171 [29%] black, 1,187 [6%] Hispanic, 348 [2%] Asian/Pacific Islander/American Indian/Alaska Native, and 2,360 [11%] declined/missing race or ethnicity) who initiated antiviral treatment with regimens containing sofosbuvir, simeprevir + sofosbuvir, ledipasvir/sofosbuvir, or paritaprevir/ombitasvir/ritonavir/dasabuvir during the 18-month period from January 1, 2014, to June 30, 2015. Overall SVR rates were 89.8% (95% confidence interval [CI] 89.2-90.4) in white, 89.8% (95% CI 89.0-90.6) in black, 86.0% (95% CI 83.7-88.0) in Hispanic, and 90.7% (95% CI 87.0-93.5) in Asian/Pacific Islander/American Indian/Alaska Native patients. However, after adjustment for baseline characteristics, black (adjusted odds ratio = 0.77, P < 0.001) and Hispanic (adjusted odds ratio = 0.76, P = 0.007) patients were less likely to achieve SVR than white patients, a difference that was not explained by early treatment discontinuations. Among genotype 1-infected patients treated with ledipasvir/sofosbuvir monotherapy, black patients had significantly lower SVR than white patients when treated for 8 weeks but not when treated for 12 weeks.

CONCLUSION:

Direct-acting antivirals produce high SVR rates in white, black, Hispanic, and Asian/Pacific Islander/American Indian/Alaska Native patients; but after adjusting for baseline characteristics, black race and Hispanic ethnicity remain independent predictors of treatment failure. Short 8-week ledipasvir/sofosbuvir monotherapy regimens should perhaps be avoided in black patients with genotype 1 hepatitis C virus. (Hepatology 2017;65:426-438).

 

 
Question posée
 
Vérifier si l’efficacité du traitement par les anti-viraux directs évaluée par la SVR est affectée par la race ou l’ethnie comme l’est celle des traitements avec l’interféron.
 
Question posée
 
L’évaluation a été faite chez les Vétérans traités par une association avec le sofosbuvir ou avec le paritaprévir : les patients noirs et hispaniques ont un taux de SVR plus bas d’environs 25% et cette diminution est significative chez les patients noirs infectés par un génotype 1 traités par sofosbuvir/ledipasvir pendant 8 semaines.
 
Commentaires

Il parait certainement prudent d’éviter les traitements courts de 8 semaines chez les patients noirs infectés par un G1.

 
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