SNFGE SNFGE
 
Thématique :
- MICI
Originalité :
Très original
Solidité :
A confirmer
Doit faire évoluer notre pratique :
Immédiatement
 
 
Nom du veilleur :
Professeur Vered ABITBOL-SELINGER
Coup de coeur :
 
 
The American Journal of Gastroenterology
  2018/05  
 
  2018 May;113(5):694-701.  
  doi: 10.1038/s41395-018-0031-x  
 
  Childhood body mass index and risk of inflammatory bowel disease in adulthood: a population-based cohort study  
 
  Jensen CB, Ängquist LH, Mendall MA, Sørensen TIA, Baker JL, Jess T  
  https://www.ncbi.nlm.nih.gov/pubmed/29535417  
 
 

Abstract

BACKGROUND:

The increasing incidence of inflammatory bowel disease (IBD) in western countries has led to the hypothesis that obesity-related inflammation could play a role in the etiology of IBD. However, this hypothesis lacks confirmation in studies of individuals prior to the typical onset of IBD in young adulthood.

METHODS:

In a cohort of 316,799 individuals from the Copenhagen School Health Records Register (CSHRR), we examined whether BMI at ages 7 through 13 years was associated with later IBD. Linking the CSHRR to the Danish National Patient Register, we identified cases of Crohn's disease (CD) and ulcerative colitis (UC) diagnosed during follow-up. Cox regression was used to estimate the hazard ratios (HR) with 95% confidence intervals.

RESULTS:

During 10 million person-years of follow-up, 1500 individuals were diagnosed with CD and 2732 with UC. At all examined ages, a 1 unit increase in BMI z-score was associated with a significantly decreased risk of UC (HRs = 0.9) and with a significantly increased risk of CD when diagnosed before age 30 (HRs = 1.2). We observed no associations between changes in BMI z-score between 7 and 13 years and later risk of CD or UC.

CONCLUSION:

We found a direct association between childhood BMI and CD diagnosed before 30 years of age, and an inverse association between childhood BMI and UC irrespective of age. Our results support the previous hypotheses of obesity being a risk factor for CD, and suggest that childhood underweight might be a risk factor for UC.

 

 
Question posée
 
Est-ce que l’indice de masse corporelle (IMC) dans l’enfance entre 7 et 13 ans est associé au risque de MICI à l’âge adulte ?
 
Question posée
 
Il existe une association directe entre l’augmentation de l’IMC dans l’enfance et le risque de maladie de Crohn chez l’adulte avant l’âge de 30 ans et une association inverse avec la RCH chez l’adulte à tout âge.
 
Commentaires

Ces résultats sont en accord avec l’hypothèse du rôle de l’obésité dans la survenue de maladie de Crohn; la maigreur de l’enfant pourrait être associée au risque de RCH à l’âge adulte.

 
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