SNFGE SNFGE
 
Thématique :
- Cancers autres (hors CCR et CHC)
Originalité :
Très original
Solidité :
A confirmer
Doit faire évoluer notre pratique :
Immédiatement
 
 
Nom du veilleur :
Professeur Sylvain MANFREDI
Coup de coeur :
 
 
Digestive and Liver Disease
  2018/03  
 
  2018 Mar;50(3):285-290.  
  doi: 10.1016/j.dld.2017.11.001  
 
  Clinical outcome of portal vein thrombosis in patients with digestive cancers: A large AGEO multicenter study  
 
  Regnault H, Emambux S, Lecomte T, Doat S, Dhooge M, Besson M, Dubreuil O, Moryoussef F, Silvain C, Bachet JB, Tougeron D  
  https://www.ncbi.nlm.nih.gov/pubmed/29183764  
 
 

Abstract

INTRODUCTION:

Management of portal vein thrombosis (PVT) in cancer patients remains discussed.

AIMS:

The objective of this multicenter retrospective study was to investigate the management and outcome of PVT in patients with digestive cancers other than hepatocellular carcinoma (HCC).

METHOD:

Main inclusion criteria were trunk or branch PVT in patients with locally advanced or metastatic digestive cancers. Predictive factors of bleeding and overall survival (OS) were evaluated in univariate and multivariate analysis.

RESULTS:

Between 2012 and 2016, 118 patients with PVT and digestive cancers were identified. The majority had a pancreatic cancer (50%). Sixty-six percent of patients had trunk PVT location. Endoscopic screening of portal hypertension was performed in only 7 patients (1%) and 5 had esophageal varices. Gastrointestinal bleeding occurred in 22 patients (19%) and 12 patient deaths (17%) were related to a gastrointestinal hemorrhage. Metastatic disease (HR=2.83 [95%CI 1.47-5.43], p<0.01) and gastrointestinal hemorrhage (HR=1.68 [95%CI 1.01-2.78], p=0.04) were associated with OS in multivariate analysis. Only trunk PVT location was significantly associated with gastrointestinal hemorrhage in multivariate analysis (HR=5.56 [95%CI 1.18-26.32], p=0.03).

CONCLUSION:

A high rate of variceal bleeding leading to death was found in this cohort. Endoscopic screening and the efficacy of prophylactic treatment of variceal bleeding remain to be evaluated in a prospective study.

 

 
Question posée
 
Impact pronostic de la thrombose porte dans les cancers digestifs hors CHC.
 
Question posée
 
Moins bon pronostic, plus de décès par hémorragie digestive. Intérêt de réaliser une FOGD +/- ligature de VO en cas de thrombose porte.
 
Commentaires

Étude rétrospective, multicentrique, sur grand effectif. 

 
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