Thématique :
- Cancer colorectal (CCR)
Originalité :
Solidité :
Très solide
Doit faire évoluer notre pratique :
Dans certains cas
Nom du veilleur :
Professeur Sylvain MANFREDI
Coup de coeur :
Digestive and Liver Disease
  2016 Oct;48(10):1112-8  
  doi: 10.1016/j.dld.2016.05.011  
  Colorectal cancer care in elderly patients: Unsolved issues  
  Aparicio T, Pamoukdjian F, Quero L, Manfredi S, Wind P, Paillaud E  

Colorectal cancers are common in elderly patients. However, cancer screening is poorly used after 75. Elderly patients form a heterogeneous population with specific characteristics. Standards of care cannot therefore be transposed from young to elderly patients. Tumour resection is frequently performed but adjuvant chemotherapy is rarely prescribed as there are no clearly established standards of care. In a metastatic setting, recent phase III studies have demonstrated that doublet front-line chemotherapy provided no survival benefit. Moreover, several studies have established the benefit of bevacizumab in association with chemotherapy. There is a lack of evidence for the efficacy of anti-epidermal growth factor antibodies in elderly patients. Geriatric assessments could help to select the adequate treatment strategy for individual patients. Geriatric oncology is now the challenge we have to face, and more specific trials are needed.

Question posée
Revue de la littérature cancer colorectal des sujets âgés.
Question posée
Nécessité de développer des études cliniques spécifiques aux sujets âgés