SNFGE SNFGE
 
Thématique :
- Endoscopie/Imagerie
Originalité :
Intermédiaire
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Dans certains cas
 
 
Nom du veilleur :
Docteur Edouard Chabrun
Coup de coeur :
 
 
Gastrointestinal Endoscopy
  2016/01  
 
  2016 Jan;83(1):117-25  
  doi: 10.1016/j.gie.2015.06.013. Epub 2015 Jul 26.  
 
  Comprehensive analysis of efficacy and safety of peroral endoscopic myotomy performed by a gastroenterologist in the endoscopy unit: a single-center experience.  
 
  Khashab MA, El Zein M, Kumbhari V, Besharati S, Ngamruengphong S, Messallam A, Abdelgalil A, Saxena P, Tieu AH, Raja S, Stein E, Dhalla S, Garcia P, Singh VK, Pasricha PJ, Kalloo AN, Clarke JO  
  http://www.ncbi.nlm.nih.gov/pubmed/?term=Comprehensive+analysis+of+efficacy+and+safety+of+peroral+endoscopic+myotomy+performed+by+a+gastroenterologist+in+the+endoscopy+unit%3A+a+single-center+experience.  
 
 

The safety and efficacy of peroral endoscopic myotomy (POEM) when performed by gastroenterologists in the endoscopy unit are currently unknown. The aims of this study were to assess (1) the safety and efficacy of POEM in which all procedures were performed by 1 gastroenterologist in the endoscopy unit, and (2) the predictors of adverse events and nonresponse.

METHODS:

All consecutive patients who underwent POEM at 1 tertiary center were included. Clinical response was defined by a decrease in the Eckardt score to 3 or lower. Adverse events were graded according to the American Society for Gastrointestinal Endoscopy lexicon's severity grading system.

RESULTS:

A total of 60 consecutive patients underwent POEM in the endoscopy suite with a mean procedure length of 99 minutes. The mean length of submucosal tunnel was 14 cm and the mean myotomy length was 11 cm. The median length of hospital stay was 1 day. Among 52 patients with a mean follow-up period of 118 days (range 30-750), clinical response was observed in 48 patients (92.3%). There was a significant decrease in Eckardt score after POEM (8 vs 1.19, P < .0001). The mean lower esophageal sphincter pressure decreased significantly after POEM (29 mm Hg vs 11 mm Hg, P < .0001). A total of 10 adverse events occurred in 10 patients (16.7%): 7 rated as mild, 3 as moderate, and none as severe. Procedure length was the only predictor of adverse events (P = .01). pH impedance testing was completed in 25 patients, and 22 (88%) had abnormal acid exposure, but positive symptom correlation was present in only 6 patients. All patients with symptomatic reflux were successfully treated with proton pump inhibitors.

CONCLUSIONS:

POEM can be effectively and safely performed by experienced gastroenterologists at a tertiary care endoscopy unit. Adverse events are infrequent, and most can be managed intraprocedurally. Post-POEM reflux is frequent but can be successfully managed medically.

 
Question posée
 
Analyse de l’efficacité et de l’inocuité de la myotomie oesophagienne endoscopique (POEM) réalisée par un gastroentérologue dans une seule unité d’endoscopie américaine.
 
Question posée
 
60 patients ont été opérés. La durée moyenne d’intervention était de 99 minutes. La myotomie était principalement antérieure. Elle s’est compliquée de 3 pneumopéritoines, un pneumothorax, 4 brèches muqueuse (ces complications étaient traitées au cours de l’endoscopie) et une embolie pulmonaire. Après un suivi moyen de 118 jours, la réponse clinique était de 92.3%. 88% des patients avaient une exposition acide anormale à la pH-métrie, 24% étaient symptomatiques.
 
Commentaires

L’efficacité décrite est comparable à celle de la littérature.

Dans cet article, ne sont pas mentionnées les modalités d’insufflation : CO2 ou air ambiant, or nous savons qu’il y a moins de complications sous CO2. Il semble qu’il y ait moins de RGO avec la myotomie postérieure (contrairement à la myotomie antérieure principalement réalisée dans cette étude),  des études comparatives sont en cours.

 
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