SNFGE SNFGE
 
Thématique :
- Colo-proctologie
Originalité :
Intermédiaire
Solidité :
Très solide
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Docteur Pauline JOUET
Coup de coeur :
 
 
The American Journal of Gastroenterology
  2018/09  
 
  2018 Sep .  
  doi: 10.1038/s41395-018-0267-5.  
 
  Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study.  
 
  Liu PH, Lebwohl B, Burke KE, Ivey KL, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H  
  https://www.ncbi.nlm.nih.gov/pubmed/30181535  
 
 

Abstract
 

OBJECTIVE:

Microscopic colitis is a common cause of chronic watery diarrhea among the elderly. Although the prevalence of celiac disease appears to be higher in patients with microscopic colitis, the relationship between dietary gluten intake and risk of microscopic colitis among individuals without celiac disease has not been explored.

METHODS:

We conducted a prospective study of 160,744 US women without celiac disease enrolled in the Nurses' Health Study (NHS) and the NHSII. Dietary gluten intake was estimated using validated food frequency questionnaires every 4 years. Microscopic colitis was confirmed through medical records review. We used Cox proportional hazard modeling to estimate the multivariable-adjusted hazard ratio (HR) and 95% confidence interval (CI).

RESULTS:

We documented 219 incident cases of microscopic colitis over more than 20 years of follow-up encompassing 3,716,718 person-years (crude incidence rate: 5.9/100,000 person-years) in NHS and NHSII. Dietary gluten intake was not associated with risk of microscopic colitis (Ptrend = 0.88). Compared to individuals in the lowest quintile of energy-adjusted gluten intake, the adjusted HR of microscopic colitis was 1.18 (95% CI: 0.77-1.78) for the middle quintile and 1.03 (95% CI: 0.67-1.58) for the highest quintile. Additional adjustment for primary dietary sources of gluten including refined and whole grains did not materially alter the effect estimates (All Ptrend ≥ 0.69). The null association did not differ according to lymphocytic or collagenous subtypes (Pheterogeneity = 0.72) and was not modified by age, smoking status, or body mass index (All Pinteraction ≥ 0.17).

CONCLUSION:

Dietary gluten intake during adulthood was not associated with risk of microscopic colitis among women without celiac disease.

 

 
Question posée
 
La colite microscopique étant plus fréquente en cas de maladie coeliaque, sa prévalence est-elle plus élevée chez les patients ayant une alimentation riche en gluten ?
 
Question posée
 
Dans cette étude portant sur 160,744 femmes américaines sans maladie coeliaque (Nurses' Health Study) suivies pendant plus de 20ans, la quantité de gluten ingérée était estimée tous les 4 ans et 219 cas de colite microscopique ont été diagnostiqués. Aucune association n’a été retrouvée entre la quantité de gluten ingérée et le risque de colite microscopique.
 
Commentaires

On ne s’était pas vraiment posé la question mais on a la réponse quand même ! Une raison de plus de ne pas exclure le gluten de l’alimentation..

 
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