Thématique :
- Endoscopie/Imagerie
Originalité :
Solidité :
Très solide
Doit faire évoluer notre pratique :
Nom du veilleur :
Professeur Emmanuel CORON
Coup de coeur :
  2016 May;65(5):806-20  
  doi: 10.1136/gutjnl-2014-308481  
  Efficacy and safety of endoscopic resection of large colorectal polyps: a systematic review and meta-analysis.  
  Hassan C, Repici A, Sharma P, Correale L, Zullo A, Bretthauer M, Senore C, Spada C, Bellisario C, Bhandari P, Rex DK  


To assess the efficacy and safety of endoscopic resection of large colorectal polyps.


Relevant publications were identified in MEDLINE/EMBASE/Cochrane Central Register for the period 1966-2014. Studies in which ≥20 mm colorectal neoplastic lesions were treated with endoscopic resection were included. Rates of postendoscopic resection surgery due to non-curative resection or adverse events, as well as the rates of complete endoscopic removal, invasive cancer, adverse events, recurrence and mortality, were extracted. Study quality was ascertained according to Newcastle-Ottawa Scale. Forest plot was produced based on random effect models. I(2) statistic was used to describe the variation across studies due to heterogeneity. Meta-regression analysis was also performed.


50 studies including 6442 patients and 6779 large polyps were included in the analyses. Overall, 503 out of 6442 patients (pooled rate: 8%, 95% CI 7% to 10%, I(2)=78.6%) underwent surgery due to non-curative endoscopic resection, and 31/6442 (pooled rate: 1%, 95% CI 0.7% to 1.4%, I(2)=0%) to adverse events. Invasive cancer at histology, non-curative endoscopic resection, synchronous lesions and recurrence accounted for 58%, 28%, 2.2% and 5.9% of all the surgeries, respectively. Endoscopic perforation occurred in 96/6595 (1.5%, 95% CI 1.2% to 1.7%) polyps, while bleeding in 423/6474 (6.5%, 95% CI 5.9% to 7.1%). Overall, 5334 patients entered in surveillance, 502/5836 (8.6%, 95% CI 7.9% to 9.3%) being lost at follow-up. Endoscopic recurrence was detected in 735/5334 patients (13.8%, 95% CI 12.9% to 14.7%), being an invasive cancer in 14/5334 (0.3%, 95% CI 0.1% to 0.4%). Endoscopic treatment was successful in 664/735 cases (90.3%, 95% CI 88.2% to 92.5%). Mortality related with management of large polyps was reported in 5/6278 cases (0.08%, 95% CI 0.01% to 0.15%).


Endoscopic resection of large polyps appeared to be an extremely effective and safe intervention. However, an adequate endoscopic surveillance is necessary for its long-term efficacy.

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to

Question posée
La résection endoscopique des gros polypes : sûre et efficace ?
Question posée
Cette méta-analyse regroupe 50 études et 6442 patients. Elle confirme les excellents résultats de la résection endoscopique des gros polypes, avec un taux de perforation faible (1,5%) et la possibilité, en cas de récidive (14%), d’un re-traitement endoscopique efficace dans 90% des cas. Le risque de survenue d’un cancer au cours de la surveillance est très faible (0,3%).

Ces résultats sont à diffuser largement pour favoriser l’adressage des gros polypes à des centres experts réalisant les larges mucosectomies ou la dissection sous-muqueuse.