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BACKGROUND AND STUDY AIMS:
The depth of invasion of the bowel wall influences the treatment of colorectal laterally spreading tumors (LSTs). The aim of this study was to evaluate the risk factors and patterns of submucosal invasion in a large series of LSTs that were removed en bloc.
PATIENTS AND METHODS:
Prospectively collected endoscopic and pathological data on a total of 822 LSTs, ≥ 10 mm in size and removed en block by endoscopic submucosal dissection (n = 670) or surgery (n = 152), were retrospectively analyzed.
RESULTS:
In 414 LSTs of the granular type, submucosal invasion was detected in 80 cases (19 %; 95 % confidence interval [CI] 16 - 23) and was deep (≥ 1000 μm) in 79 % of cases. The invasion site was under a large (≥ 10 mm) nodule (56 %), depression (28 %), or was multifocal (16 %). Risk factors for deep submucosal invasion on multivariate analysis were the presence of a large nodule (odds ratio [OR] 12, 95 %CI 2 - 59), depression (OR 59, 95 %CI 9 - 387), and invasive pit pattern (OR 33, 95 %CI 12 - 88). The sensitivity and specificity of invasive pit pattern for detection of deep submucosal invasion were 52 % (95 %CI 40 % - 64 %) and 98 % (95 %CI 96 % - 99 %), respectively.In 408 LSTs of the nongranular type, submucosal invasion was detected in 159 cases (39 %; 95 %CI 34 - 44) and was deep in 54 % of cases. The invasion site was under a submucosal mass-like elevation (10 %), depression (45 %), or was multifocal (45 %). Risk factors for deep submucosal invasion were the presence of a submucosal mass-like elevation (OR 8, 95 %CI 1 - 61), depression (OR 28, 95 %CI 8 - 97), and invasive pit pattern (OR 79, 95 %CI 25 - 256).
CONCLUSIONS:
Because of a substantial risk of submucosal invasion and multifocal invasion, granular type LSTs with a large nodule or depression and nongranular type LSTs should be endoscopically removed en bloc.
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Etude prospective japonaise monocentrique de 822 LST de plus de 10 mm réséquées en monobloc par dissection sous-muqueuse endoscopique (n=670) et par chirurgie (n=152).
Pour les LST granuleuses, l’invasion sous-muqueuse était retrouvée dans 79% des cas. Les facteurs de risque étaient : présence d’un large nodule de plus de 10mm, d’une zone déprimée et d’un pit pattern péjoratif.
Pour les LST non granuleuses, l’invasion sous-muqueuse était retrouvée dans 39% des cas. Les facteurs de risqu étaient : présence d’une surélévation sous-muqueuse, d’une zone déprimée et d’un pit pattern péjoratif.
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