SNFGE SNFGE
 
Thématique :
- Œsophage/Estomac
Originalité :
Très original
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Docteur Pauline JOUET
Coup de coeur :
 
 
Gastroenterology
  2016/01  
 
  2015 Dec;149(7):1742-51  
  doi: 10.1053/j.gastro.2015.08.005. Epub 2015 Aug 14.  
 
  The Functional Lumen Imaging Probe Detects Esophageal Contractility Not Observed With Manometry in Patients With Achalasia.  
 
  Carlson DA, Lin Z, Kahrilas PJ, Sternbach J, Donnan EN, Friesen L, Listernick Z, Mogni B, Pandolfino JE  
  http://www.ncbi.nlm.nih.gov/pubmed/?term=Gastroenterology.+2015+Dec%3B149%287%29%3A1742-51.+doi%3A+10.1053%2Fj.gastro.2015.08.005.+Epub+2015+Aug+14.  
 
 

BACKGROUND & AIMS:

The functional lumen imaging probe (FLIP) could improve the characterization of achalasia subtypes by detecting nonocclusive esophageal contractions not observed with standard manometry. We aimed to evaluate esophageal contractions during volumetric distention in patients with achalasia using FLIP topography.

METHODS:

Fifty-one treatment-naive patients with achalasia, defined and subclassified by high-resolution esophageal pressure topography, and 10 asymptomatic individuals (controls) were evaluated with the FLIP during endoscopy. During stepwise distension, simultaneous intrabag pressures and 16 channels of cross-sectional areas were measured; data were exported to software that generated FLIP topography plots. Esophageal contractility was identified by noting periods of reduced luminal diameter. Esophageal contractions were characterized further by propagation direction, repetitiveness, and based on whether they were occluding or nonoccluding.

RESULTS:

Esophageal contractility was detected in all 10 controls: 8 of 10 had repetitive antegrade contractions and 9 of 10 had occluding contractions. Contractility was detected in 27% (4 of 15) of patients with type I achalasia and in 65% (18 of 26, including 9 with occluding contractions) of patients with type II achalasia. Contractility was detected in all 10 patients with type III achalasia; 8 of these patients had a pattern of contractility that was not observed in controls (repetitive retrograde contractions).

CONCLUSIONS:

Esophageal contractility not observed with manometry can be detected in patients with achalasia using FLIP topography. The presence and patterns of contractility detected with FLIP topography may represent variations in pathophysiology, such as mechanisms of panesophageal pressurization in patients with type II achalasia. These findings could have implications for additional subclassification to supplement prediction of the achalasia disease course.

 
Question posée
 
Quel est l’apport du système Endoflip par rapport à la manométrie haute résolution pour enregistrer les contractions du corps de l’œsophage lors de distension œsophagienne volumétrique chez 51 patients adultes ayant une achalasie (10 type I, 19 type II, 7 type III) et 10 volontaires sains asymptomatiques ?
 
Question posée
 
Chez des patients ayant une achalasie, l’Endoflip permet de détecter des contractions œsophagiennes dans 27% (type I), 65% (type II) et 100% (type III) des cas.
 
Commentaires

L’endoflip semble avoir un intérêt dans l’étude de la motricité oesophagienne de patients ayant une achalasie. La signification clinique et pronostique des profils moteurs décrits dans cette étude doivent être précisées dans des études ultérieures.

 
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