High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patients With Ulcerative Colitis in Remission During Treatment With Aminosalicylates. | SNFGE.org - Société savante médicale française d'hépato-gastroentérologie et d’oncologie digestive
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Thématique :
- MICI
Originalité :
Intermédiaire
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Immédiatement
 
 
Nom du veilleur :
Docteur Stéphane NAHON
Coup de coeur :
 
 
Clinical Gastroenterology and Hepatology
  2017/09  
 
  2017 Sep;15(9):1390-1396.e1  
  doi: 10.1016/j.cgh.2016.12.036  
 
  High Dietary Intake of Specific Fatty Acids Increases Risk of Flares in Patients With Ulcerative Colitis in Remission During Treatment With Aminosalicylates.  
 
  Barnes EL, Nestor M, Onyewadume L, de Silva PS, Korzenik JR; DREAM Investigators  
  https://www.ncbi.nlm.nih.gov/pubmed/28110099  
 
 

Abstract

BACKGROUND & AIMS:

Dietary factors may have a significant role in relapse of disease among patients with ulcerative colitis (UC). However, the relationship between diet and UC is inadequately understood. We analyzed data from the diet's role in exacerbations of mesalamine maintenance study to determine whether dietary factors affect the risk of disease flares in patients with UC.

METHODS:

We performed a prospective, multicenter, observational study of 412 patients, from 25 sites, with UC in remission during monotherapy with an aminosalicylate. Patients completed a validated food frequency questionnaire at enrollment and were followed for 12 months. We analyzed the relationship between diet and disease remission or flare for groups of macronutrients and micronutrients, and food groups previously associated with an increased risk of flare.

RESULTS:

Forty-five patients (11%) had a UC relapse within 1 year of study enrollment. When analyzed in tertiles, increasing intake of multiple fatty acids was associated with increasing odds of relapse. In multivariable logistic regression analysis, only myristic acid (odds ratio, 3.01; 95% confidence interval, 1.17-7.74) maintained this dose-response relationship. Other foods previously implicated in flares of UC, such as processed meat, alcohol, and foods high in sulfur, were not associated with an increased risk of flare.

CONCLUSIONS:

In a prospective study of more than 400 patients with UC undergoing treatment with aminosalicylates, we associated high dietary intake of specific fatty acids, including myristic acid (commonly found in palm oil, coconut oil, and dairy fats) with an increased risk of flare. These findings can help design interventional studies to evaluate dietary factors in UC.

 

 
Question posée
 
La consommation de certains acides gras est-elle associée à un risque de rechute de la RCH en rémission sous 5-ASA?
 
Question posée
 
Dans cette étude prospective, les patients ayant une RCH en rémission sous 5 ASA, ont plus de récidive en cas d’alimentation riche en certains acides gras (notamment en acide myristique : huile de palme, l’huile de coco et les matières grasses animales).
 
Commentaires

Ce travail prospectif montre un effet d’une alimentation riche en certaines graisses sur la rechute de la RCH plaidant pour l’hypothèse environnementale dans la genèse des MICI mais également aussi dans la rechute de la maladie. Mangez bio pour ne pas rechuter !

 
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