SNFGE SNFGE
 
Thématique :
- Colo-proctologie
- Cancer colorectal (CCR)
Originalité :
Intermédiaire
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Docteur Vincent DE PARADES
Coup de coeur :
 
 
Colorectal Disease
  2018/11  
 
  2018 Nov;20(11):961-969.  
  doi: 10.1111/codi.14416.  
 
  Human papillomavirus infection and colorectal cancer in the Chinese population: a meta-analysis.  
 
  Zhang XH, Wang W, Wang YQ, Jia DF, Zhu L  
  https://www.ncbi.nlm.nih.gov/pubmed/30199598  
 
 

Abstract

AIM:

Human papillomavirus (HPV) infection has been reported in colorectal cancer in many studies. We conducted a meta-analysis to assess the association between HPV infection and colorectal cancer/adenomas in the Chinese population.

METHOD:

Relevant studies up to January 2018 were searched in PubMed, EMBASE, China National Knowledge Infrastructure and the Wanfang database. We used a random effects model to determine the prevalence of HPV and odds ratios (ORs) with 95% confidence intervals (CIs). The I2 statistic and P-value from the Cochrane Q-test were used to describe the heterogeneity.

RESULTS:

Ten case-control studies involving 766 colorectal cancer patients and 470 controls were included in the meta-analysis. Among the colorectal cancer patients, the pooled prevalence was 0.45 (95% CI 0.36-0.53). The pooled estimate for OR was 10.78 (95% CI 4.22, 27.53). Among the 193 patients with colorectal adenoma, the pooled prevalence and OR were 0.31 (95% CI 0.24-0.37) and 2.03 (95% CI 0.79, 5.26), respectively. The prevalence of HPV 16 and HPV 18 among HPV-positive cancers ranged from 57.9% to 100% and 0% to 39.7%, respectively.

CONCLUSION:

The results indicated that HPV infection, especially HPV 16 and HPV 18, is associated with colorectal cancer in the Chinese population.

 
 
Question posée
 
Y-a-t-il un lien entre l’infection par les papillomavirus humains et le cancer colo-rectal ?
 
Question posée
 
Cette méta-analyse de 10 études cas-contrôles chinoises a montré que des papillomavirus humains, surtout les génotypes 16 et 18, étaient présents dans 58 à 100 % des cancers colorectaux étudiés (versus 0 à 40 % chez les sujets contrôles). L'Odds Ratio était de 10,78 (95% CI = 4,22 – 27,53).
 
Commentaires

Cet article conforte des données récentes rapportées ailleurs dans le monde.

Encore un argument pour la vaccination contre les papillomavirus humains oncogènes ?

 
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