Thématique :
- Foie
- Carcinome hépatocellulaire (CHC)
Originalité :
Solidité :
Doit faire évoluer notre pratique :
Pas encore
Nom du veilleur :
Professeur Jean-Marie PERON
Coup de coeur :
  2017 Mar;152(4):812-820.e5.  
  doi: 10.1053/j.gastro.2016.11.020  
  Incidence of Hepatocellular Carcinoma in All 50 United States, From 2000 Through 2012.  
  White DL, Thrift AP, Kanwal F, Davila J, El-Serag HB  



The incidence and mortality of hepatocellular carcinoma (HCC) have been reported to be plateauing in the United States. The United States has large racial, ethnic, and regional variation; we collected data from all 50 states to better analyze changes in HCC incidence in the entire United States.


We collected data from the US Cancer Statistics registry, which covers 97% of the population, and calculated adjusted incidence rates. We assessed annual trends among sociodemographic and geographic subgroups using joinpoint analysis.


HCC incidence increased from 4.4/100,000 in 2000 to 6.7/100,000 in 2012, increasing by 4.5% (95% confidence interval [CI], 4.3%-4.7%) annually between 2000 and 2009, but only by 0.7% annually (95% CI, -0.2% to 1.6%) from 2010 through 2012. The average annual percentage change (AAPC) between 2000 and 2012 was higher in men (increase, 3.7%) than in women (increase, 2.7%), and highest in 55- to 59-year-old individuals (AAPC, 8.9%; 95% CI, 7.1%-10.7%) and 60- to 64-year-old individuals (AAPC, 6.4%; 95% CI, 4.7%-8.2%). By 2012, rates in Hispanics surpassed those in Asians, and rates in Texas surpassed those in Hawaii (9.71/100,000 vs 9.68/100,000). Geographic variation within individual race and ethnic groups was observed, but rates were highest in all major race and ethnic groups in Texas.


In an analysis of the incidence of HCC in all 50 US states, we found the rate of increase in HCC to have slowed from 2010 through 2012. However, incidence is increasing in subgroups such as men ages 55 to 64 years old-especially those born in the peak era of hepatitis C virus infection and among whites/Caucasians. Rates in Hispanics have surpassed those in Asian Americans. We observed geographic differences, with Texas having the highest age-adjusted HCC rates nationwide.

Question posée
Evaluation de l’incidence du CHC aux US entre 2000 et 2012.
Question posée
Diminution du taux d’accroissement de l’incidence du CHC à partir de 2010. Hétérogénéité de l’incidence du CHC aux US. L’incidence chez les hispaniques dépasse pour la première fois l’incidence chez les asiatiques.

L’incidence du CHC aux US varie en fonction des régions et des étiologies. Il en est de même en France (cf Goutté et al. JHepatol Mar 2017).