Thématique :
- Cancers autres
Originalité :
Très original
Solidité :
A confirmer
Doit faire évoluer notre pratique :
Pas encore
Nom du veilleur :
Professeur Thomas APARICIO
Coup de coeur :
  2017 Aug. pii: gutjnl-2017-314281.  
  doi: 10.1136/gutjnl-2017-314281.  
  Mucosal microbiome dysbiosis in gastric carcinogenesis.  
  Coker OO, Dai Z, Nie Y, Zhao G, Cao L, Nakatsu G, Wu WK, Wong SH, Chen Z, Sung JJY, Yu J  



We aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.


We performed 16S rRNA gene analysis of gastric mucosal samples from 81 cases including superficial gastritis (SG), atrophic gastritis (AG), intestinal metaplasia (IM) and gastric cancer (GC) from Xi'an, China, to determine mucosal microbiome dysbiosis across stages of GC. We validated the results in mucosal samples of 126 cases from Inner Mongolia, China.


We observed significant mucosa microbial dysbiosis in IM and GC subjects, with significant enrichment of 21 and depletion of 10 bacterial taxa in GC compared with SG (q<0.05). Microbial network analysis showed increasing correlation strengths among them with disease progression (p<0.001). Five GC-enriched bacterial taxa whose species identifications correspond to Peptostreptococcus stomatisStreptococcus anginosusParvimonas micraSlackia exigua and Dialister pneumosintes had significant centralities in the GC ecological network (p<0.05) and classified GC from SG with an area under the receiver-operating curve (AUC) of 0.82. Moreover, stronger interactions among gastric microbes were observed in Helicobacter pylori-negative samples compared with H. pylori-positive samples in SG and IM. The fold changes of selected bacteria, and strengths of their interactions were successfully validated in the Inner Mongolian cohort, in which the five bacterial markers distinguished GC from SG with an AUC of 0.81.


In addition to microbial compositional changes, we identified differences in bacterial interactions across stages of gastric carcinogenesis. The significant enrichments and network centralities suggest potentially important roles of P. stomatisD. pneumosintesS. exiguaP. micra and S. anginosus in GC progression.


Question posée
Le microbiote gastrique est-il associé aux lésions pré-néoplasiques gastriques ?
Question posée

Après le cancer du côlon le rôle du microbiote pointe son nez dans la carcinogénèse gastrique. Ces données préliminaires sont à confirmer mais Hélicobacter pylori n’est peut-être plus seul.