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Originalité :
Intermédiaire
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Immédiatement
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Journal of Crohn's and Colitis
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2016/08
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J Crohns Colitis 11 (2), 165-174. 2016 Aug
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DOI: 10.1093/ecco-jcc/jjw145
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Patient-reported Outcomes in a French Nationwide Survey of Inflammatory Bowel Disease Patients.
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Nicolas Williet, Hélène Sarter, Corinne Gower-Rousseau, Charlotte Adrianjafy, Alain Olympie, Anne Buisson, Laurent Beaugerie, Laurent Peyrin-Biroulet
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https://www.ncbi.nlm.nih.gov/labs/articles/27516406/
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BACKGROUND: Patient reported-outcomes [PROs] are a major therapeutic goal in inflammatory bowel disease [IBD].
METHODS: Between January and June 2014, patients affiliated with the French national IBD association filled out six self-questionnaires: quality of life 9QoL, according to the Short Inflammatory Bowel Disease Questionnaire [SIBDQ] and the Short-Form-36 Questionnaire [SF-36] v2); fatigue (the Functional Assessment of Chronic Illness Therapy-Fatigue [FACIT-F]); work productivity (the Work Productivity and Activity Impairment [WPAI] questionnaire); disability [the I nflammatory Bowel Disease Disability Index]; and anxiety/depression (the Hospital Anxiety and Depression scale [HADS]). Associated factors were identified by univariate and multivariate logistic regression analyses.
RESULTS: Datasets were obtained from 1185 IBD patients. Around half of patients reported poor QoL [SIBDQ 7: 49.4%]. One-third of the patients reported anxiety [HAD-A >7: 30.3%] and/or moderate [22.4%] or severe [11.9%] disability. About half of them reported presenteeism and moderate-to-severe loss of work productivity and loss of activity. Poor QoL, severe fatigue, severe disease-related disability, and/or high WPAI were all associated with female gender, unemployment, and disease activity. Poor QoL, severe fatigue, and high WPAI were also associated with the use of tumour necrosis factor antagonists. A history of surgery was associated with poor QoL, whereas age was associated with severe fatigue. Severe depression was associated with female gender and disease activity.
CONCLUSIONS: The disease burden is very high in IBD, with poor QoL, fatigue, work impairment, and depression in half of patients. Marked disability and anxiety were reported by one-third of patients.
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Les “patient reported-outcomes [PROs]” sont un des objectifs thérapeutiques majeurs dans les MICI.
Les malades affiliés à l’association française des MICI ont rempli 6 auto-questionnaires : qualité de vie, fatigue, productivité au travail, handicap, anxiété/dépression.
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Les données ont été recueillies chez 1185 patients atteints de MICI.
Plus de la moitié des malades présentait une altération de la qualité de vie, une fatigue, une diminution de la productivité au travail, ou une dépression. Un tiers des malades présentait un handicap ou une anxiété significative.
Le sexe féminin, l’absence d’emploi et l’activité de la maladie étaient associés à une altération de la qualité de vie, une fatigue, une diminution de la productivité au travail, ou une dépression.
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L’impact des MICI sur la qualité de vie, la fatigue, la productivité au travail, le handicap, l’anxiété et la dépression, est majeur et concerne plus de la moitié des malades.
Ces paramètres doivent être davantage pris en compte dans le traitement des patients.
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