SNFGE SNFGE
 
Thématique :
- Carcinome hépatocellulaire (CHC)
- Foie
Originalité :
Réexamen
Solidité :
A confirmer
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Professeur Sylvain MANFREDI
Coup de coeur :
 
 
British journal of Cancer
  2015/09  
 
  2015 Sep;113(5):756-62  
  doi: 10.1038/bjc.2015.227  
 
  Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma  
 
  Sadeghi M, Lahdou I, Oweira H, Daniel V, Terness P, Schmidt J, Weiss K, Longerich T, Schemmer P, Opelz G, Mehrabi A  
  http://www.ncbi.nlm.nih.gov/pubmed/26270232  
 
 

Background
Most hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage. The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited. The aim of our study is to evaluate the diagnostic value of serum growth factors, apoptotic and inflammatory mediators of cirrhotic patients with and without HCC.

Methods
Serum samples were collected from cirrhotic potential liver transplant patients (LTx) with (n¼61) and without HCC (n¼78) as well as from healthy controls (HCs; n¼39). Serum concentrations of CRP, neopterin and IL-6 as markers of inflammation and thrombopoietin (TPO), GCSF, FGF basic and VEGF, HMGB1, CK-18 (M65) and CK18 fragment (M30) and a panel of proinflammatory chemokines (CCL2, CCL3, CCL4, CCL5, CXCL5 and IL-8) were measured. Chi square, Fisher exact, Mann–Whitney U-tests, ROC curve analysis and forward stepwise logistic regression analyses were applied.

Results
Patients with HCC had higher serum TPO and chemokines (Po0.001 for TPO, CCL4, CCL5 and CXCL5) and lower CCL2 (P¼0.008) levels than cirrhotic patients without HCC. Multivariate forward stepwise regression analysis for significant parameters showed that among the studied parameters CCL4 and CCL5 (P¼0.001) are diagnostic markers of HCC. Serum levels of TPO and chemokines were lower, whereas M30 was significantly higher in cirrhotic patients than in HCs.

Conclusions
High serum levels of inflammatory chemokines such as CCL4 and CCL5 in the serum of cirrhotic patients indicate the presence of HCC.

 
Question posée
 
Recherche d’un marqueur sérique permettant le diagnostic précoce, voire le dépistage du CHC sur cirrhose.
 
Question posée
 
Les patients cirrhotiques porteurs de CHC ont des dosages de CCL4 et CCL5 sériques élevés. Ces dosages pourraient à l’avenir permettre la détection précoce du CHC.
 
Commentaires

Etude préliminaire prometteuse, à confirmer sur de plus larges effectifs, en prospectif.

 
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