SNFGE SNFGE
 
Thématique :
- Cancers autres
Originalité :
Très original
Solidité :
A confirmer
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Professeur Thomas APARICIO
Coup de coeur :
 
 
Gut
  2015/11  
 
  2015 Nov;64(11):1721-31  
  doi: 10.1136/gutjnl-2014-308252. Epub 2014 Nov 10.  
 
  Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas  
 
  Lin SJ, Gagnon-Bartsch JA, Tan IB, Earle S, Ruff L, Pettinger K, Ylstra B, van Grieken N, Rha SY, Chung HC, Lee JS, Cheong JH, Noh SH, Aoyama T, Miyagi Y, Tsuburaya A, Yoshikawa T, Ajani JA, Boussioutas A, Yeoh KG, Yong WP, So J, Lee J, Kang WK, Kim S, Kameda Y, Arai T, Zur Hausen A, Speed TP, Grabsch HI, Tan P  
  http://www.ncbi.nlm.nih.gov/pubmed/?term=Signatures+of+tumour+immunity+distinguish+Asian+and+non-Asian+gastric+adenocarcinomas  
 
 

OBJECTIVE:

Differences in gastric cancer (GC) clinical outcomes between patients in Asian and non-Asian countries has been historically attributed to variability in clinical management. However, recent international Phase III trials suggest that even with standardised treatments, GC outcomes differ by geography. Here, we investigated gene expression differences between Asian and non-Asian GCs, and if these molecular differences might influence clinical outcome.

DESIGN:

We compared gene expression profiles of 1016 GCs from six Asian and three non-Asian GC cohorts, using a two-stage meta-analysis design and a novel biostatistical method (RUV-4) to adjust for technical variation between cohorts. We further validated our findings by computerised immunohistochemical analysis on two independent tissue microarray (TMA) cohorts from Asian and non-Asian localities (n=665).

RESULTS:

Gene signatures differentially expressed between Asians and non-Asian GCs were related to immune function and inflammation. Non-Asian GCs were significantly enriched in signatures related to T-cell biology, including CTLA-4 signalling. Similarly, in the TMA cohorts, non-Asian GCs showed significantly higher expression of T-cell markers (CD3, CD45R0, CD8) and lower expression of the immunosuppressive T-regulatory cell marker FOXP3 compared to Asian GCs (p<0.05). Inflammatory cell markers CD66b and CD68 also exhibited significant cohort differences (p<0.05). Exploratory analyses revealed a significant relationship between tumour immunity factors, geographic locality-specific prognosis, and postchemotherapy outcomes.

CONCLUSIONS:

Analyses of >1600 GCs suggest that Asian and non-Asian GCs exhibit distinct tumour immunity signatures related to T-cell function. These differences may influence geographical differences in clinical outcome, and the design of future trials particularly in immuno-oncology.

 
Question posée
 
Existe-t-il des différences biologiques entre les adénocarcinomes gastriques chez les patients asiatiques vs non asiatiques ?
 
Question posée
 
Oui, notamment pour la signature immunologique.
 
Commentaires

Une explication autre qu’une prise en charge déficiente des patients occidentaux ! Ces résultats sont importants à prendre en compte pour de futures études d’immunothérapie.

 
www.snfge.org