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Thématique :
- MICI
Originalité :
Très original
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Immédiatement
 
 
Nom du veilleur :
Coup de coeur :
 
 
Journal of Crohn's and Colitis
  2018/04  
 
  2018 Apr ;12(5):559-567.  
  doi: 10.1093/ecco-jcc/jjy005.  
 
  Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women.  
 
  Burke KE, Ananthakrishnan AN, Lochhead P, Olen O, Ludvigsson JF, Richter JM, Chan AT, Khalili H  
  https://www.ncbi.nlm.nih.gov/pubmed/29370359  
 
 

Abstract

BACKGROUND:

Long-term data on the influence of smoking on risk of microscopic colitis are limited. We therefore sought to examine and characterize the association between smoking and risk of incident microscopic colitis in two large prospective cohorts of women.

METHODS:

We conducted a prospective study of 231015 women enrolled in the Nurses' Health Study [NHS] and NHSII. Information regarding smoking, other lifestyle factors and medications were collected biennially from 1976 to 2012 in NHS and from 1989 to 2013 in NHSII. Incident cases of microscopic colitis were confirmed through physician medical record review. We used Cox proportional hazards modelling to examine the association between smoking and risk of microscopic colitis.

RESULTS:

We documented 166 incident cases of microscopic colitis over 6122779 person-years of follow up. Compared to non-smokers, the multivariable-adjusted hazard ratio [HR] for microscopic colitis was 2.52 (95% confidence interval [CI] 1.59-4.00) amongst current smokers and 1.54 [95% CI 1.09-2.17] amongst past smokers. The risk increased with higher pack-years of smoking [p trend = 0.001] and diminished following smoking cessation [p trend = 0.017]. Current smoking appeared to be more strongly associated with risk of collagenous colitis [HR 3.68; 95% CI 1.94-6.97] than lymphocytic colitis [HR 1.71; 95% CI 0.83-3.53].

CONCLUSION:

In two large prospective cohort studies, we observed an association between current smoking and risk of microscopic colitis. Risk of microscopic colitis appeared to increase with higher pack-years and diminish following smoking cessation. Future studies focused on characterizing the biological mechanisms underlying these associations are warranted.

 

 
Question posée
 
Existe-t-il une association entre tabagisme et risque de développer une colite microscopique ?
 
Question posée
 
Oui. Dans deux études prospectives de forte puissance, il existe une association entre tabagisme actif et risque de colite microscopique. Le risque de colite microscopique semble corrélé aux nombres de paquets années et diminué avec le sevrage tabagique.
 
Commentaires

Le sevrage tabagique doit être obtenu en cas de suspicion de colite microscopique.

 
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