SNFGE SNFGE
 
Thématique :
- Intestin/Nutrition/Troubles fonctionnels
- Colo-proctologie
Originalité :
Intermédiaire
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Pas encore
 
 
Nom du veilleur :
Docteur Pauline JOUET
Coup de coeur :
 
 
Gastroenterology
  2017/11  
 
  2017 Nov;153(5):1230-1239.  
  doi: 10.1053/j.gastro.2017.07.017.  
 
  Superficial Esophageal Mucosal Afferent Nerves may Contribute to Reflux Hypersensitivity in Nonerosive Reflux Disease.  
 
  Woodland P, Shen Ooi JL, Grassi F, Nikaki K, Lee C, Evans JA, Koukias N, Triantos C, McDonald SA, Peiris M, Aktar R, Blackshaw LA, Sifrim D  
  https://www.ncbi.nlm.nih.gov/pubmed/28734832  
 
 

Abstract

BACKGROUND & AIMS:

Little is known about the causes of heartburn in patients with gastro-esophageal reflux disease. Visible epithelial damage is seldom associated with symptom severity, evidenced by the significant symptom burden in patients with nonerosive reflux disease (NERD) compared with patients with erosive reflux disease (ERD) or Barrett's esophagus (BE). We studied the distribution of mucosal nerve fibers in patients with NERD, ERD, and BE, and compared the results with those of healthy subjects.

METHODS:

We performed a prospective study of 13 patients with NERD, 11 patients with ERD, and 16 patients with BE undergoing endoscopic evaluation in the United Kingdom or Greece. Biopsies were obtained from the proximal and distal esophageal mucosa of patients with NERD, from the distal esophageal mucosa of patients with ERD, and the distal-most squamous epithelium of patients with BE. These were examined for the presence and location of nerve fibers that reacted with a labeled antibody against calcitonin gene-related peptide (CGRP), a marker of nociceptive sensory nerves. The results were compared with those from 10 healthy volunteers (controls).

RESULTS:

The distribution of CGRP-positive nerves did not differ significantly between the distal esophageal mucosa of controls (median, 25.5 cell layers to surface; interquartile range [IQR], 21.4-28.8) vs patients with ERD (median, 23 cell layers to surface; IQR, 16-27.5), or patients with BE (median, 21.5 cell layers to surface; IQR, 16.1-27.5). However, CGRP-positive nerves were significantly more superficial in mucosa from patients with NERD-both distal (median, 9.5 cell layers to surface; IQR, 1.5-13.3; P < .0001 vs ERD, BE, and controls) and proximal (median, 5.0 cell layers to surface; IQR, 2.5-9.3 vs median 10.4 cell layers to surface; IQR, 8.0-16.9; P = .0098 vs controls).

CONCLUSIONS:

Proximal and distal esophageal mucosa of patients with NERD have more superficial afferent nerves compared with controls or patients with ERD or BE. Acid hypersensitivity in patients with NERD might be partially explained by the increased proximity of their afferent nerves to the esophageal lumen, and therefore greater exposure to noxious substances in refluxate.

 

 
Question posée
 
La distribution des fibres nerveuses afférente dans la muqueuse oesophagienne est-elle différente entre les patients ayant un RGO sans oesophagite, avec oesophagite érosive ou avec un endobrachyoesophage, en comparaison à des volontaires sains ?
 
Question posée
 
Les fibres nerveuses étudiées sur des biopsies de muqueuse oesophagienne avec un marqueur des nerfs sensitifs nociceptifs, les anticorps anti-Calcitonin-Gene-Related-Peptide (CGRP), sont plus souvent localisées à la superficie de la muqueuse chez les patients ayant un RGO sans oesophagite en comparaison avec ceux ayant une oesophagite érosive, un endobrachyoesophage ou avec les volontaires sains.
 
Commentaires

Le RGO sans oesophagite pourrait avoir un mécanisme physiopathologique différent avec un intérêt à développer des traitements locaux susceptibles d’agir sur les fibres nerveuses de localisation plus superficielle dans cette indication.

 
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