SNFGE SNFGE
 
Thématique :
- Foie
Originalité :
Intermédiaire
Solidité :
Intermédiaire
Doit faire évoluer notre pratique :
Dans certains cas
 
 
Nom du veilleur :
Docteur Jean-Louis PAYEN
Coup de coeur :
 
 
Journal of Hepatology
  2019/04  
 
  2019 Apr;70(4):674-683.  
  doi: 10.1016/j.jhep.2018.12.001.  
 
  The trends in incidence of primary liver cancer caused by specific etiologies: Results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention  
 
  Liu Z, Jiang Y, Yuan H, Fang Q, Cai N, Suo C, Jin L, Zhang T, Chen X  
  https://www.ncbi.nlm.nih.gov/pubmed/30543829  
 
 

Abstract

BACKGROUND & AIMS:

Liver cancer is a common malignant neoplasm worldwide. The etiologies for liver cancer are diverse and the incidence trends of liver cancer caused by specific etiologies are rarely studied. We therefore aimed to determine the pattern of liver cancer incidence, as well as temporal trends.

METHODS:

We collected detailed information on liver cancer etiology between 1990-2016, derived from the Global Burden of Disease study in 2016. Estimated annual percentage changes (EAPCs) in liver cancer age standardized incidence rate (ASR), by sex, region, and etiology, were calculated to quantify the temporal trends in liver cancer ASR.

RESULTS:

Globally, incident cases of liver cancer increased 114.0% from 471,000 in 1990 to 1,007,800 in 2016. The overall ASR increased by an average 0.34% (95% CI 0.22%-0.45%) per year in this period. The ASR of liver cancer due to hepatitis B, hepatitis C, and other causes increased between 1990 and 2016. The corresponding EAPCs were 0.22 (95% CI 0.08-0.36), 0.57 (95% CI 0.48-0.66), and 0.51 (95% CI 0.41-0.62), respectively. The ASR of liver cancer due to reported alcohol use remained stable (EAPC = 0.10, 95% CI -0.06-0.25). This increasing pattern was heterogeneous across regions and countries. The most pronounced increases were generally observed in countries with a high socio-demographic index, including the Netherlands, the UK, and the USA.

CONCLUSIONS:

Liver cancer remains a major public health concern globally, though control of hepatitis B and C virus infections has contributed to the decreasing incidence in some regions. We observed an unfavorable trend in countries with a high socio-demographic index, suggesting that current prevention strategies should be reoriented, and much more targeted and specific strategies should be established in some countries to forestall the increase in liver cancer.

LAY SUMMARY:

Liver cancer is a common malignant neoplasm worldwide. The incidence patterns of liver cancer caused by different etiologies varied considerably across the world. In this study, we aim to determine the pattern of liver cancer incidence as well as the temporal trends, thereby facilitating the establishment of more tailored prevention strategies for liver cancer.

 
  
Question posée
 
Evolution de l'incidence du cancer primitif du foie en fonction des étiologies spécifiques : résultats de l'étude mondiale sur la morbidité 2016 et implications pour la prévention du cancer du foie.
  
Question posée
 
Le cancer primitif du foie reste une préoccupation majeure de santé publique dans le monde, bien que le contrôle des infections par les virus de l'hépatite B et C ait contribué à la diminution de l'incidence dans certaines régions. Les auteurs ont observé une tendance à l’augmentation de l’incidence dans les pays à indice socio-démographique élevé, ce qui suggère que les stratégies de prévention actuelles devraient être réorientées et que des stratégies beaucoup plus ciblées et spécifiques devraient être mises en place dans certains pays pour prévenir l’augmentation du cancer du foie.
  
Commentaires

On peut comprendre aisément ces variations d’incidence compte tenu de la très grande disparité mondiale d’accès au soin, à la prévention … encore fallait-il l’objectiver, c’est donc le fruit de ce travail.
 
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